Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function.
Benjamin LidgardNisha BansalLeila R ZelnickAndrew HoofnagleJing ChenDerek ColaizzoMirela DobreKatherine T MillsAnna C PorterSylvia E RosasMark J SarnakStephen L SeligerJames H SondheimerManjula Kurella TamuraKristine YaffeBryan R Kestenbaumnull nullPublished in: Journal of the American Society of Nephrology : JASN (2022)
Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. Further work is needed to determine the domains of cognition most affected by decreased secretory clearance and the mechanisms of these associations.