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IGF-1 and risk of morbidity and mortality from cancer, cardiovascular diseases, and all-causes in EPIC - Heidelberg.

Trasias MukamaBernard SrourTheron JohnsonVerena KatzkeRudolf Kaaks
Published in: The Journal of clinical endocrinology and metabolism (2023)
This large population-based prospective study showed that both individuals with lowest and highest levels of circulating IGF-1 were at increased risk of deaths from cancer, cardiovascular and all-causes. For individuals with low IGF-1, the excess risks of death were more pronounced among individuals with liver cancer and cirrhosis but were also present among individuals without elevated liver enzymes.
Keyphrases
  • papillary thyroid
  • cardiovascular disease
  • binding protein
  • squamous cell
  • pi k akt
  • coronary artery disease
  • lymph node metastasis
  • squamous cell carcinoma
  • risk assessment
  • signaling pathway
  • human health