Microbial Cell-Free DNA Identifies the Causative Pathogen in Infective Endocarditis and Remains Detectable Longer Than Conventional Blood Culture in Patients with Prior Antibiotic Therapy.

Emily M EichenbergerNicholas DegnerErick R ScottFelicia RuffinJohn FranzoneBatu Sharma-KuinkelPratik ShahDavid HongSudeb C DalaiLily BlairDesiree HollemonEliza ChangCarine HoLisa WandaChristiaan de VriesVance G FowlerAsim A Ahmed

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

mcfDNA accurately identifies the microbial etiology of IE. Sequential mcfDNA levels may ultimately help to individualize therapy by estimating a patient's burden of infection and response to treatment.

Keyphrases

microbial community
genome wide
case report
risk factors
gene expression
candida albicans
cell therapy
bone marrow
smoking cessation