A facile oxygen-17 NMR method to determine effective viscosity in dilute, molecularly crowded and confined aqueous media.

Nasrollah Rezaei-Ghaleh Francesca Munari Stefan Becker Michael Assfalg Christian Griesinger

Published in: Chemical communications (Cambridge, England) (2019)

We present an NMR method based on natural abundance 17O relaxation of water to determine effective viscosity in biological aqueous samples. The method accurately captures viscosity of dilute and crowded protein solutions and offers a fairly simple way to quantify the internal fluidity of biological condensates formed through phase separation.

Keyphrases

magnetic resonance
high resolution
ionic liquid
solid state
quantum dots
small molecule
gold nanoparticles