Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.
Jinyun ChenQian WangXuebing FengZhuoya ZhangLinyu GengTing XuDandan WangLingyun SunPublished in: Stem cells international (2016)
Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). In this study, we showed that T cells from SLE patients had higher autophagic activity than that from healthy controls. A correlation between autophagic activity and apoptotic rate was observed in activated T cells. Moreover, activation of autophagy with rapamycin increased T cell apoptosis, whereas inhibition of autophagy with 3-MA decreased T cell apoptosis. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) could inhibit respiratory mitochondrial biogenesis in activated T cells to downregulate autophagy and consequently decrease T cell apoptosis through mitochondrial transfer and thus may play an important role in SLE treatment.
Keyphrases
- cell death
- umbilical cord
- mesenchymal stem cells
- oxidative stress
- endoplasmic reticulum stress
- systemic lupus erythematosus
- signaling pathway
- cell proliferation
- disease activity
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- bone marrow
- respiratory tract
- patient reported outcomes
- combination therapy