Origin and significance of leucine-rich glioma-inactivated 1 antibodies in cerebrospinal fluid.
Fang ZhangHong ZhouYujie YiNa LiMiaomiao LiuHuijun ShenYingshi GuoJie WangPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
LGI1-Ab CSF-positive patients have higher serum titers, and their CSF titers are positively correlated with serum titers, indicating a possible peripheral origin of CSF LGI1-Abs. CSF-positive patients more often present with psychiatric symptoms, hyponatremia, and worse outcomes, suggesting more severe neuronal damage.