Interrupted Click Reaction with CuCF 2 CF 3 Reagent: Synthesis of 5-Pentafluoroethyl 1,2,3-Triazoles.

We herein describe a three-component interrupted click reaction to synthesize novel 5-pentafluoroethyl 1,2,3-triazoles in one step from readily available terminal alkynes and azides. The key reagent [CuCF 2 CF 3 ], prepared from the low-cost gas pentafluoroethane, demonstrates an orthogonal reactivity in facilitating cycloaddition rather than previously reported radical reactions. Reaction conditions are mild by using air as a green oxidant.