Cyclometalated platinum(II) complex as a selective light switch for G-quadruplex DNA.

Published in: Dalton transactions (Cambridge, England : 2003) (2023)

Cyclometalated 1,3-bis(8-quinolyl) phenyl chloroplatinum(II) (Pt1) shows selective luminescence transduction of G-quadruplex binding over duplex DNA. The effect is enhanced on association with parallel and hybrid G-quadruplex structures over other topologies. The kinetics of binding are studied for c-myc and the response is found to be partially reversible in a displacement assay.

Keyphrases

circulating tumor
cell free
single molecule
dna binding
nucleic acid
high resolution
quantum dots
binding protein
ionic liquid
circulating tumor cells
transcription factor