Extrarenal Signs of Proximal Renal Tubular Acidosis Persist in Nonacidemic Nbce1b/c-Null Mice.

Emily E SalernoSangita P PatelAniko MarshallJordan MarshallThamer AlsufayanCheikh S Alassane MballoBianca N QuadeMark D Parker

Published in: Journal of the American Society of Nephrology : JASN (2019)

The correction of pRTA-related acidemia should not be considered a panacea for all signs of pRTA. The phenotype of Nbce1b/c-null mice highlights the physiologic importance of NBCe1 variants expressed beyond the proximal tubular epithelia and potential limitations of pH correction by alkali therapy in pRTA. It also suggests a novel genetic locus for corneal dystrophy and enamel hypomineralization without acidemia.

Keyphrases

high fat diet induced
copy number
early onset
optical coherence tomography
wild type
type diabetes
insulin resistance
climate change