Interfering with lysophosphatidic acid receptor edg2/lpa1 signalling slows down disease progression in SOD1-G93A transgenic mice.

Ángela Gento-CaroEsther Vilches-HerrandoVictoria García-MoralesFederico PortilloGuillermo Rodríguez-BeyDavid González-ForeroBernardo Moreno-López

Published in: Neuropathology and applied neurobiology (2021)

These results suggest that stressed lpa-lpa1 signalling contributes to MN degeneration in SOD1-G93A mice. Consequently, disrupting lpa1 slows down disease progression. This highlights LPA1 signalling as a potential target and/or biomarker in ALS.

Keyphrases

amyotrophic lateral sclerosis
risk assessment
adipose tissue
high fat diet induced
room temperature
binding protein