Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer.

Ge MaYi JiangMengdi LiangJiaYing LiJingyi WangXinrui MaoJordee Selvamanee VeeramootooTiansong XiaXiaoan LiuShui Wang

Published in: Therapeutic advances in medical oncology (2020)

We determined that aneuploid CEC dynamics vary in patients with different response to chemotherapy. Elucidating the potential cross-talk between CTCs and aneuploid CECs may help characterize the process associated with the development of chemotherapy resistance and metastasis.

Keyphrases

locally advanced
neoadjuvant chemotherapy
rectal cancer
squamous cell carcinoma
endothelial cells
radiation therapy
phase ii study
sentinel lymph node
circulating tumor cells
copy number
risk assessment
lymph node
human health
early stage
young adults
study protocol
placebo controlled