Cyperane and eudesmane-type sesquiterpenoids from Chinese liverwort and their anti-diabetic nephropathy potential.
Jiaozhen ZhangYongjie WangRongxiu ZhuYi LiYuelan LiYanan QiaoJinchuan ZhouHong-Xiang LouPublished in: RSC advances (2018)
Six new sesquiterpenoids, including cyperane (1 and 2) and eudesmane (3-6) types, and one known eudesmane derivative (7), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis (Schrad.) Nees. The structures of 1-7 were determined based on a combination of their spectroscopic data (NMR, HRESIMS and IR), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Preliminary anti-diabetic nephropathy activity testing showed that the cyperane-type sesquiterpenoids could inhibit cell proliferation and extracellular matrix accumulation in high glucose cultured mesangial cells in a dose-dependent manner.
Keyphrases
- diabetic nephropathy
- extracellular matrix
- high glucose
- endothelial cells
- high resolution
- cell proliferation
- induced apoptosis
- molecular docking
- magnetic resonance
- cell cycle arrest
- solid state
- electronic health record
- density functional theory
- molecular dynamics
- cell cycle
- big data
- molecular dynamics simulations
- pi k akt
- magnetic resonance imaging
- electron microscopy
- oxidative stress
- cell death
- mass spectrometry
- signaling pathway
- risk assessment
- endoplasmic reticulum stress
- water soluble
- human health