Case-Control and Family-Based Association Study of Specific PTPRD Variants in Restless Legs Syndrome.
Ziv Gan OrSirui ZhouAmelie JohnsonJacques Y MontplaisirRichard P AllenChristopher J EarleyAlex DesautelsPatrick A DionLan XiongGuy A RouleauPublished in: Movement disorders clinical practice (2016)
Although the PTPRD gene is well established as an RLS-associated locus, the rs2381970 SNP and the 3 nonsynonymous PTPRD variants are not likely to cause or affect the risk for developing RLS in the study population. More studies in other populations are needed to determine their potential role in RLS.