Effect of Locally Delivered Nimodipine Microparticles on Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage.

Andrew P CarlsonAmal AlchbliDaniel HänggiR Loch MacdonaldC William Shuttleworth

Published in: Neurocritical care (2021)

These results are consistent with a beneficial effect of locally delivered nimodipine (EG-1962) on SD after aSAH in more severely injured patients who are at risk of delayed cerebral ischemia related to SD. Larger studies are warranted to test this effect.

Keyphrases

subarachnoid hemorrhage
cerebral ischemia
end stage renal disease
brain injury
ejection fraction
chronic kidney disease
newly diagnosed
blood brain barrier
prognostic factors
drug induced