Migraine-associated gene expression in cell types of the central and peripheral nervous system.
Angeliki VgontzasWilliam RenthalPublished in: Cephalalgia : an international journal of headache (2019)
Single-cell RNA sequencing of the brain and peripheral nervous system localizes each migraine-associated gene to its respective nervous system tissue and the cell types in which it is expressed. While the majority of migraine-associated genes are broadly expressed, we identified several cell-type-specific migraine-associated genes in the central nervous system, peripheral nervous system, and neurovasculature. Trial registration: not applicable.
Keyphrases
- single cell
- rna seq
- gene expression
- genome wide
- genome wide identification
- high throughput
- cell therapy
- dna methylation
- chemotherapy induced
- clinical trial
- copy number
- stem cells
- white matter
- resting state
- phase ii
- bioinformatics analysis
- cerebral ischemia
- functional connectivity
- brain injury
- bone marrow
- transcription factor
- subarachnoid hemorrhage
- blood brain barrier