Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.
Maruthi Kumar NarayanamGaoyuan MaPier Alexandre ChampagneKendall N HoukJennifer M MurphyPublished in: Angewandte Chemie (International ed. in English) (2017)
A practical method for radiofluorination of anilines with [18 F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18 F-labeling to prepare [18 F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18 F-labeled neuropeptide.