Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas.

Jurik A Mutter Stefan K AligMohammad S EsfahaniEliza M Lauer Jan Mitschke David M Kurtz Julia KühnSabine BleulMari OlsenChih Long Liu Michael C Jin Charles W Macaulay Nicolas Neidert Timo VolkMichel EisenblaetterSebastian RauerDieter Henrik Heiland Juergen FinkeJustus DuysterJulius WehrleMarco PrinzGerald IllerhausPeter Christoph ReinacherElisabeth SchorbMaximilian DiehnAsh A Alizadeh Florian Scherer

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

We demonstrate robust and ultrasensitive detection of ctDNA at various disease milestones in CNSL. Our findings highlight the role of ctDNA as a noninvasive biomarker and its potential value for personalized risk stratification and treatment guidance in patients with CNSL.

Keyphrases

circulating tumor
cell free
circulating tumor cells
label free
loop mediated isothermal amplification
real time pcr
machine learning
gold nanoparticles
deep learning
white matter
quantum dots
cerebral ischemia
blood brain barrier
high resolution
single molecule
brain injury