Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells.
Luke S CoxMarisol Alvarez-MartinezXuemei WuLeona GabryšováRaphaëlle LuisierJames BriscoeNicholas M LuscombeAnne O'GarraPublished in: Wellcome open research (2023)
These data show that Blimp-1 and c-Maf positively and negatively regulate a network of both unique and common anti-inflammatory and pro-inflammatory genes to reinforce a Th1 response in mice that will eradicate pathogens with minimum immunopathology.
Keyphrases
- anti inflammatory
- genome wide
- induced apoptosis
- genome wide identification
- cell cycle arrest
- dendritic cells
- electronic health record
- copy number
- regulatory t cells
- gram negative
- skeletal muscle
- high fat diet induced
- cell proliferation
- antimicrobial resistance
- deep learning
- immune response
- data analysis
- genome wide analysis
- network analysis