High- and low-dose oral immunotherapy similarly suppress pro-allergic cytokines and basophil activation in young children.
Michael D KulisXiaohong YueRishu GuoHuamei ZhangKelly OrgelPing YeQuefeng LiYutong LiuEdwin KimArvil Wesley BurksBrian P VickeryPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Peanut OIT leads to decreases in pro-allergic cytokines, including IL-5, IL-13, and IL-9 and decreased basophil activation. No differences in T cell or basophil responses were found between subjects on low or high-dose maintenance OIT, which has implications for clinical dosing strategies.