ROS-Responsive Blended Nanoparticles: Cascade-Amplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process.
Pengying WuWei DongXuyan GuoXiaoyang QiaoShifang GuoLei ZhangMingxi WanYujin ZongPublished in: Advanced healthcare materials (2019)
Sonodynamic therapy (SDT) not only has greater tissue-penetrating depth compared to photo-stimulated therapies, but also can also trigger rapid drug release to achieve synergistic sonochemotherapy. Here, reactive oxygen species (ROS)-responsive IR780/PTL- nanoparticles (NPs) are designed by self-assembly, which contain ROS-cleavable thioketal linkers (TL) to promote paclitaxel (PTX) release during SDT. Under ultrasound (US) stimulation, IR780/PTL-NPs produce high amounts of ROS, which not only induces apoptosis in human glioma (U87) cells but also boosts PTX released by decomposing the ROS-sensitive TL. In the U87 tumor-bearing mouse model, the IR780/PTL-NPs releases the drug at the target sites in a controlled manner upon US irradiation, which significantly inhibits tumor growth and induces apoptosis in the tumor tissues with no obvious toxicity. Taken together, the IR780/PTL-NPs are a novel platform for sonochemotherapy, and can control the spatio-temporal release of chemotherapeutic drugs during SDT.
Keyphrases
- reactive oxygen species
- drug release
- cell death
- dna damage
- drug delivery
- cancer therapy
- mouse model
- cell cycle arrest
- oxide nanoparticles
- endothelial cells
- magnetic resonance imaging
- induced apoptosis
- oxidative stress
- stem cells
- gene expression
- emergency department
- bone marrow
- cell proliferation
- induced pluripotent stem cells
- replacement therapy
- sensitive detection
- contrast enhanced ultrasound