Familial risk of epithelial ovarian cancer after accounting for gynaecological surgery: a population-based study.
Mollie E BarnardHuong MeeksElke A JarboeJames AlbroNicola J CampJennifer A DohertyPublished in: Journal of medical genetics (2022)
Familial risk of epithelial ovarian cancer extends to TDRs, especially for high-grade serous and mucinous histotypes. Distant relatives share genes but minimal environment, highlighting the importance of germline inherited genetics in ovarian cancer aetiology. Increased ovarian cancer risk in distant relatives has implications for counselling and recommendations for prophylactic surgeries that, from our data, appear only to reach FDRs.
Keyphrases
- high grade
- low grade
- lymph node
- early onset
- minimally invasive
- coronary artery bypass
- genome wide
- electronic health record
- dna repair
- big data
- clinical practice
- surgical site infection
- smoking cessation
- gene expression
- hiv testing
- artificial intelligence
- acute coronary syndrome
- dna damage
- machine learning
- hiv infected