An Immunological Axis Involving Interleukin 1β and Leucine-Rich-α2-Glycoprotein Reflects Therapeutic Response of Children with Kawasaki Disease: Implications from the KAWAKINRA Trial.
Christoph KesselIsabelle Koné-PautStéphanie TellierAlexandre BelotKatja MasjosthusmannHelmut WittkowskiSabrina FuehnerLinda Rossi-SemeranoPerrine DusserIsabelle MarieNadja BoukhedouniHelène AgostiniCéline PiedvacheDirk FoellPublished in: Journal of clinical immunology (2022)
Our study identifies LRG1 as known trigger of endothelial activation and cardiac re-modeling to associate with IL-1β signaling in KD. Besides a potential patho-mechanistic implication of these findings, our data suggest blood leukocyte and neutrophil counts to best predict response to IL-1Ra treatment in IVIG-resistant KD.