Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.

Colleen Lacey Theone S E PatersonJodie R Gawryluknull null

Published in: PloS one (2024)

The current study partially replicated and extended previous findings from an earlier multimodal study (Honea 2009). Future studies should clarify APOE mechanisms in healthy ageing by adding other imaging, cognitive, and lifestyle metrics and longitudinal design in larger sample sizes.

Keyphrases

physical activity
cardiovascular disease
metabolic syndrome
high resolution
type diabetes
high fat diet
white matter
weight loss
adipose tissue
blood brain barrier