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Real-World Efficacy and Safety of an 8-Week Glecaprevir/Pibrentasvir Regimen in Children and Adolescents with Chronic Hepatitis C-Results of a Multicenter EpiTer-2 Study.

Małgorzata PawłowskaKrystyna DobrowolskaJustyna MoppertMaria Pokorska-ŚpiewakMariola PurzynskaMagdalena MarczyńskaDorota Zarębska-MichalukRobert Flisiak
Published in: Journal of clinical medicine (2023)
The aim of the study was to analyze the effectiveness and safety of anti-HCV treatment based on a pangenotypic direct-acting antiviral (DAA) regimen with glecaprevir/pibrentasvir (GLE/PIB) in children. The multi-center study was conducted in HCV-infected children who were treated in the period from November 2022 to January 2023. The analysis included 23 pediatric patients with a mean (SD) age of 9.61 (3.68) years. The cohort included 13 girls and 10 boys. The most common HCV genotypes were GT1b ( n = 9, 39.1%), GT1a ( n = 6, 26.1%) and GT3 ( n = 5, 21.7%). The SVR was assessed at 12 weeks after the end of treatment and was 100% for both girls and boys. The conducted study showed a very good tolerance of the treatment in the entire analyzed group and confirmed a very high efficacy and safety for 8-week treatment with GLE/PIB in children over three years of age. It seems that our study is the first on the real-world use of an 8-week GLE/PIB pangenotypic therapy in a group of children aged 3-12 years and the first in Europe for adolescents aged 12-17.
Keyphrases
  • young adults
  • hepatitis c virus
  • stem cells
  • physical activity
  • mesenchymal stem cells
  • computed tomography
  • bone marrow
  • cell therapy
  • replacement therapy
  • smoking cessation
  • double blind