eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in Mice.
Drishya IyerDiandra M MastrogiacomoKunyu LiRicha BanerjeeYing YangJoshua P ScallanPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
In conclusion, we demonstrate a novel, NO-independent role for eNOS in regulating lymphatic valve specification and propose a mechanism by which eNOS directly binds β-catenin to regulate its nuclear translocation and thereby transcriptional activity.
Keyphrases
- nitric oxide synthase
- pi k akt
- aortic valve
- endothelial cells
- mitral valve
- lymph node
- aortic stenosis
- nitric oxide
- cell proliferation
- cell fate
- signaling pathway
- epithelial mesenchymal transition
- gene expression
- transcatheter aortic valve replacement
- transcription factor
- high fat diet induced
- type diabetes
- ejection fraction
- heart failure
- coronary artery disease
- oxidative stress
- left ventricular
- heat shock
- genome wide identification
- heat shock protein