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Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature.

Hilde K GjelbergLars HelgelandKnut LisethFrancesca MicciMiriam SandnesHege G RussnesHåkon Reikvam
Published in: Current oncology (Toronto, Ont.) (2023)
T-prolymphocytic leukemia (T-PLL) is a rare malignancy of mature T-cells with distinct clinical, cytomorphological, and molecular genetic features. The disease typically presents at an advanced stage, with marked leukocytosis, B symptoms, hepatosplenomegaly, and bone marrow failure. It usually follows an aggressive course from presentation, and the prognosis is often considered dismal; the median overall survival is less than one year with conventional chemotherapy. This case report describes a patient with T-PLL who, after an unusually protracted inactive phase, ultimately progressed to a highly invasive, organ-involving disease. After initial treatments failed, a novel treatment approach resulted in a significant response.
Keyphrases
  • case report
  • bone marrow
  • acute myeloid leukemia
  • mesenchymal stem cells
  • genome wide
  • locally advanced
  • dna methylation
  • sleep quality
  • replacement therapy