Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia.

Ruggiero AlessandraCaldrer SaraPastori ClaudiaGianesini NatashaCugnata FedericaBrombin ChiaraFantoni TobiaTais StefanoRizzi EleonoraMatucci AndreaMayora-Neto MartinUberti-Foppa CaterinaTemperton NigelDi Serio Mariaclelia StefaniaLopalco LuciaPiubelli Chiara

Published in: Journal of translational medicine (2024)

Administration of 3 vaccination doses reduces the severe symptomatology in aged and elderly. Vaccination showed a strong association with anti-SARS-CoV-2 humoral response and an expansion of Th2 T-cells populations, independently of age. Delta variants and number of vaccine doses affected the magnitude of the humoral response against the original SARS-CoV-2 and emerging variants. A systematic surveillance of the emerging variants is paramount to define future vaccination strategies.

Keyphrases

sars cov
copy number
immune response
respiratory syndrome coronavirus
public health
middle aged
current status
gene expression
community dwelling
genome wide