Preimplantation genetic haplotyping for six Chinese pedigrees with thalassemia using a single nucleotide polymorphism microarray.

Xu LiuYanwen XuJishan SunZheng ZhangJing WangChenhui DingS Lilly ZhengJianfeng XuCanquan Zhou

Published in: Prenatal diagnosis (2017)

This simple SNP-based PGH method offers simultaneous haplotyping and human leukocyte antigen matching, which facilitates the determination of optimal embryos for IVF with high accuracy. Further studies are needed to help improve this method into clinic utility. © 2017 John Wiley & Sons, Ltd.

Keyphrases

genome wide
endothelial cells
primary care
dna methylation
solid phase extraction
pregnant women
copy number
mass spectrometry
pregnancy outcomes
sickle cell disease
high density
gene expression
high resolution