Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles.

Rosie M WalkerKadi VaherMairead L BerminghamStewart W MorrisAndrew D BretherickYanni ZengKonrad RawlikCarmen AmadorArchie CampbellChris S HaleyCaroline HaywardDavid J PorteousAndrew M McIntoshRiccardo E MarioniKathryn L Evans

Published in: Genome medicine (2021)

APOE ε4 vs. ε2 carrier status is associated with epigenome-wide methylation differences in the blood. The loci identified are located in trans as well as cis to APOE and implicate genes involved in lipid homeostasis.

Keyphrases

dna methylation
cognitive decline
genome wide
high fat diet
gene expression
mild cognitive impairment
insulin resistance