Effect of lethal total body irradiation on bone marrow chimerism, acute graft-versus-host disease, and tumor engraftment in mouse models: impact of different radiation techniques using low- and high-energy X-rays.
Nhu Hanh ToCaroline PilonAudrey MoattiAnaïs DebessetKamel DebbiGabriele CoraggioWassim KsouriVirginie MassariaJosé L CohenYazid BelkacemiAllan ThiolatPublished in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2023)
Different X‑ray irradiation modalities condition T cell alloreactivity in experimental semi-allogeneic BMT. Low-energy X‑ray irradiator induces a post-TBI inflammatory burst and exacerbates alloreactive reactions. This technical and biological information should be considered in interpreting GVHD/ graft-versus-leukemia effect results in mice experimental models of BMT.
Keyphrases
- bone marrow
- high resolution
- allogeneic hematopoietic stem cell transplantation
- dual energy
- mouse model
- mesenchymal stem cells
- liver failure
- traumatic brain injury
- radiation induced
- stem cell transplantation
- hematopoietic stem cell
- acute myeloid leukemia
- respiratory failure
- high frequency
- electron microscopy
- oxidative stress
- computed tomography
- high fat diet induced
- drug induced
- magnetic resonance imaging
- healthcare
- radiation therapy
- low dose
- metabolic syndrome
- mass spectrometry
- hepatitis b virus
- extracorporeal membrane oxygenation
- social media
- skeletal muscle