Cldn4 overexpression promotes penile cavernous smooth muscle cell fibrotic response via the JNK signaling pathway.

Huang JieWang JieGuo YingxueZhang XinXu RunnanHuang WenjieJian Xiong Ma Bo-Dong Lv

Published in: The journal of sexual medicine (2024)

CCSMC hypoxia leads to increased Cldn4, in both nerve injury and diabetic ED rat models, and promotes fibrosis by activating the JNK signaling pathway.

Keyphrases

signaling pathway
smooth muscle
pi k akt
induced apoptosis
epithelial mesenchymal transition
emergency department
single cell
type diabetes
oxidative stress
cell therapy
systemic sclerosis
cell proliferation
idiopathic pulmonary fibrosis
prostate cancer
mesenchymal stem cells
wound healing
peripheral nerve