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AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Peter M BenzYindi DingHeike StinglAnnemarieke E LootJoana ZinkIlka WittigRüdiger PoppIngrid Fleming
Published in: Acta physiologica (Oxford, England) (2019)
The results suggest that compartmentalized AKAP12/PKA signalling mediates VASP phosphorylation at the leading edge of migrating endothelial cells to translate angiogenic stimuli into altered actin dynamics and cell movement.
Keyphrases
  • cell migration
  • endothelial cells
  • high glucose
  • vascular endothelial growth factor
  • single cell
  • cell therapy
  • diabetic rats
  • protein kinase
  • stem cells
  • drug induced
  • oxidative stress
  • mesenchymal stem cells