Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.

Xiaodong ShiYing YangSiqi ShangSongfang WuWeina ZhangLijun PengTing HuangRuihong ZhangRuibao RenJianqing MiYue-Ying Wang

Published in: BMC cancer (2019)

This study showed that cooperation of DNMT3A mutation and NRAS mutation could promote the onset of AML by synergistically disturbing the transcriptional profiling with Myc pathway involvement in DKI mice.

Keyphrases

wild type
dna methylation
high fat diet induced
transcription factor
acute myeloid leukemia
gene expression
single cell
type diabetes
allogeneic hematopoietic stem cell transplantation
insulin resistance
metabolic syndrome
acute lymphoblastic leukemia
oxidative stress
heat shock protein