Electroretinographic abnormalities associated with pregabalin: a case report.

Wakana NinomiyaKei Mizobuchi Takaaki HayashiSachiyo OkudeSatoshi KatagiriAkiko KuboNami MasuharaTadashi Nakano

Published in: Documenta ophthalmologica. Advances in ophthalmology (2020)

This is the first report to indicate that ERG abnormalities might be associated with pregabalin treatment. Our results suggest that pregabalin may affect LTCC function via the α2-δ1/α2-δ2 subunits, which leads to defective synaptic transmission from rod/cone photoreceptors to bipolar cells.

Keyphrases

neuropathic pain
postoperative pain
induced apoptosis
cell cycle arrest
spinal cord
spinal cord injury
bipolar disorder
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway