Recent Advances in Chronotherapy Targeting Respiratory Diseases.
Keshav Raj PaudelSaurav Kumar JhaVenkata Sita Rama Raju AllamParteek PrasherPiyush Kumar GuptaRahul BhattacharjeeNiraj Kumar JhaSukriti VishwasSachin K SinghJesus ShresthaMohammad ImranNisha PanthDinesh Kumar ChellappanMajid Ebrahimi WarkianiPhilip Michael HansbroKamal DuaPublished in: Pharmaceutics (2021)
Respiratory diseases contribute to a significant percentage of mortality and morbidity worldwide. The circadian rhythm is a natural biological process where our bodily functions align with the 24 h oscillation (sleep-wake cycle) process and are controlled by the circadian clock protein/gene. Disruption of the circadian rhythm could alter normal lung function. Chronotherapy is a type of therapy provided at specific time intervals based on an individual's circadian rhythm. This would allow the drug to show optimum action, and thereby modulate its pharmacokinetics to lessen unwanted or unintended effects. In this review, we deliberated on the recent advances employed in chrono-targeted therapeutics for chronic respiratory diseases.
Keyphrases
- lung function
- atrial fibrillation
- heart rate
- cancer therapy
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- respiratory tract
- small molecule
- physical activity
- genome wide
- high frequency
- emergency department
- type diabetes
- stem cells
- coronary artery disease
- depressive symptoms
- dna methylation
- drug induced
- amino acid
- drug delivery
- transcription factor
- genome wide analysis