Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.
Soon Yew TangRonan LordanHu MengBenjamin J AuerbachElizabeth J HennessyArjun SenguptaUjjalkumar S DasRobin JoshiOscar A Marcos-ContrerasRyan McConnellGregory R GrantEmanuela RicciottiVladimir R MuzykantovTilo GrosserAalim M WeiljieGarret A FitzGeraldPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.