Comparative whole-exome sequencing of an ultra-late recurrent malignant melanoma.

When malignant melanoma does not recur within 15 years after treatment, the patient's survival and victory over the high-grade cancer are celebrated. Ultra-late recurrence, i.e., recurrence after more than 15 disease-free years, is very rare (1, 2). This phenomenon is not well analysed because obtaining samples with intact DNA for detailed analyses of tumour tissue stored for such a long time has been considered impossible.