EGFR mutations are associated with response to depatux-m in combination with temozolomide and result in a receptor that is hypersensitive to ligand.

Youri HoogstrateWies VallentgoedJohan M KrosIris de HeerMaurice de WitMarica EoliJuan Manuel SepulvedaAnnemiek M E WalenkampJean-Sebastien FrenelEnrico FranceschiPaul M ClementMicheal WellerMartin E van RoyenPeter AnsellJim LoomanEarle BainMarie MorfouaceThierry GorliaVassilis GolfinopoulosMartin van den BentPim J French

Published in: Neuro-oncology advances (2019)

These data can help guide treatment for recurrent glioblastoma patients and increase our understanding into the molecular mechanisms underlying EGFR signaling in these tumors.

Keyphrases

small cell lung cancer
newly diagnosed
epidermal growth factor receptor
end stage renal disease
tyrosine kinase
ejection fraction
prognostic factors
electronic health record
deep learning
single molecule
patient reported
combination therapy
artificial intelligence