Maladaptive autophagy in the pathogenesis of autoimmune epithelitis in Sjӧgren's Syndrome.
Serena ColafrancescoC BarbatiRoberta PrioriE PutroF GiardinaA GattamelataB MonosiTania ColasantiA I CeliaB CerbelliC GiordanoS ScarpaM FusconiGiulio CavalliO BerardicurtiS GandolfoS NayarF BaroneR GiacomelliS De VitaC AlessandriFabrizio ContiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
In pSS SGECs, inflammation induces autophagy and pro-survival mechanisms, which promote SGEC activation and mirror histological severity. These findings indicate that autophagy is a central contributor to the pathogenesis of pSS and a new therapeutic target.