Laser-assisted topical delivery of vismodegib reduces hedgehog gene expression in human basal cell carcinomas in vivo.

Uffe Hoegh Olesen Kristian Kåber Pedersen Katrine Togsverd-Bo Edyta BiskupAnni Linnet NielsenMalene Jackerott Gael Clergeaud Thomas Lars Andresen Merete Haedersdal

Published in: Lasers in surgery and medicine (2024)

A single AFL-assisted topical application of vismodegib resulted in clinically relevant intratumoral drug concentrations and significant reductions in hedgehog pathway gene expressions.

Keyphrases

basal cell carcinoma
gene expression
endothelial cells
dna methylation
single cell
wound healing
genome wide
cell therapy
induced pluripotent stem cells
high grade
copy number
genome wide identification
mesenchymal stem cells
bone marrow