Intermittent Exposure of Hypercapnia Suppresses Allograft Rejection via Induction of Treg Differentiation and Inhibition of Neutrophil Accumulation.
Yuan-Sheng TzengYi-Jen PengShih-En TangKun-Lun HuangShi-Jye ChuShu-Yu WuChia-Pi ChengPublished in: Biomedicines (2022)
Serum levels of IFN-γ, IL-2, IL-6, and TNF-α were significantly decreased in the HCA group. Additionally, the percentage of CD8+ cells in draining lymph nodes was significantly lower in HCA than in the control group. Moreover, the generation rate of FoxP3+ regulatory T cells (Tregs) from spleen naïve CD4+ T cells was increased by intermittent exposure to carbon dioxide. The infiltrated neutrophils were also eliminated by HCA. Taken together, we concluded that intermittent hypercapnia exposure could effectively suppress skin rejection by stimulating Treg cell generation and suppressing immune reactions.
Keyphrases
- regulatory t cells
- carbon dioxide
- dendritic cells
- high intensity
- lymph node
- induced apoptosis
- signaling pathway
- single cell
- rheumatoid arthritis
- immune response
- cell cycle arrest
- cell therapy
- endoplasmic reticulum stress
- soft tissue
- oxidative stress
- stem cells
- neoadjuvant chemotherapy
- early stage
- mesenchymal stem cells
- pi k akt
- kidney transplantation
- nk cells