Impact of Prior TB Treatment with New/Companion Drugs on Clinical Outcomes in Patients Receiving Concomitant Bedaquiline and Delamanid for MDR/RR-TB.

L MikiashviliRussell R KempkerTs ChakhaiaN BablishviliZ AvalianiN LomtadzeM C SchechterM Kipiani

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

Prior exposure to new/companion TB drugs was associated with poor clinical outcomes and acquired drug resistance. Tailoring the TB regimen to each patient's DST results and burden of disease and enhancing adherence support may improve outcomes.

Keyphrases

mycobacterium tuberculosis
multidrug resistant
drug resistant
case report
skeletal muscle
combination therapy
glycemic control
weight loss