The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity.
Daniela Maria TanaseEvelina Maria GosavSmaranda RaduClaudia Florida CosteaManuela CiocoiuAlexandru CarauleanuCristina-Mihaela LăcătușuMinela Aida MaranducaMariana FloriaCiprian RezusPublished in: International journal of molecular sciences (2019)
Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.
Keyphrases
- acute kidney injury
- induced apoptosis
- oxidative stress
- endoplasmic reticulum stress
- inflammatory response
- cardiac surgery
- signaling pathway
- high glucose
- dna damage
- ischemia reperfusion injury
- lipopolysaccharide induced
- clinical practice
- big data
- toll like receptor
- lps induced
- metabolic syndrome
- drug induced
- cell proliferation
- drug administration
- case control
- heat stress
- cell cycle arrest
- artificial intelligence