Cytotoxic flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through UCK2 modulation of the STAT3/Hif-1α/VEGF signalling pathway.

Ibrahim MalamiAlhassan AlhassanAdamu AdamuMuhammad BelloAliyu MuhammadMustapha Imam

Published in: Current drug targets (2023)

Our data suggest that FKB inhibited HepG2 proliferation and further suppressed its metastasis partly by regulating the STAT3/Hif-1α/VEGF signalling pathway. FKB could be a potential alternative and viable strategy against HCC.

Keyphrases

endothelial cells
vascular endothelial growth factor
cell proliferation
electronic health record
signaling pathway
big data
risk assessment
data analysis
machine learning
climate change
anti inflammatory