ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway.
Haoran LiuQin HuKe RenPengxin WuYang WangChuanzhu LvPublished in: Molecular medicine (Cambridge, Mass.) (2023)
We demonstrated that ALDH2 alleviated LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING signaling pathway, thereby protecting against LPS-induced cardiac injury. This study identifies a novel therapeutic approach for treating sepsis-induced cardiomyopathy (SIC).
Keyphrases
- lps induced
- oxidative stress
- inflammatory response
- diabetic rats
- left ventricular
- signaling pathway
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest
- heart failure
- cell death
- pi k akt
- epithelial mesenchymal transition
- genome wide
- radiation therapy
- gene expression
- dna methylation
- cell proliferation
- drug induced
- atrial fibrillation
- cancer stem cells
- high temperature