Sex hormones differentially contribute to Parkinson's disease in males: a multimodal biomarker study.
Roberta BovenziGiulia Maria SancesarioMatteo ContiPiergiorgio GrilloRocco CerroniJacopo BissaccoPaolo FortiEmilia GiannellaMassimo PieriSilvia MinosseValentina FerrazzoliNoemi PucciMario LaudaziRoberto FlorisFrancesco GaraciMariangela PierantozziAlessandro StefaniNicola Biagio MercuriEliseo PicchiFrancesca Di GiulianoTommaso SchirinziPublished in: European journal of neurology (2023)
The study suggested that sex hormones could differentially contribute to clinical-pathological features of PD in male patients. While estradiol might have a protective role in motor impairment, testosterone might be involved in male vulnerability to PD neuropathology. Gonadotropins instead might mediate age-dependent phenomena of amyloidopathy and cognitive decline.