Dynamics of leucocyte DNA thioguanine nucleotide levels during maintenance therapy of childhood acute lymphoblastic leukemia.

Rikke Hebo LarsenLisa Lyngsie HjalgrimMatilda DegnJacob NerstingBodil Als-NielsenKathrine GrellKjeld Schmiegelow

Published in: Cancer chemotherapy and pharmacology (2021)

Fluctuations in DNA-TGTotal are predominantly caused by corresponding fluctuations in DNA-TGPMN, thus DNA-TGTotal measures recent TGN incorporation in these short-lived cells. Measurement of DNA-TGTotal at 2-4 weeks intervals provides a reliable profile of DNA-TG levels.

Keyphrases

circulating tumor
cell free
single molecule
acute lymphoblastic leukemia
nucleic acid
circulating tumor cells
stem cells
cell death
bone marrow
young adults
cell cycle arrest
mesenchymal stem cells
pi k akt
early life