Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness.

Martin SchwersenskyMarianne RoomanFabrizio Pucci

Published in: BMC biology (2020)

Our results highlight the non-universality of mutational robustness and its multiscale dependence on protein features, the structure of the genetic code, and the codon usage. Our analyses and approach are strongly supported by available experimental mutagenesis data.

Keyphrases

genome wide
crispr cas
protein protein
amino acid
binding protein
dna methylation
electronic health record
molecular docking
gene expression
small molecule
big data
machine learning
deep learning
molecular dynamics simulations