Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits.
Alexander G MathioudakisWim JanssensPradeesh SivapalanAran SinganayagamMark T DransfieldJens-Ulrik Stæhr JensenJørgen VestboPublished in: Thorax (2020)
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.
Keyphrases
- cancer therapy
- chronic obstructive pulmonary disease
- drug delivery
- lung function
- liver failure
- respiratory failure
- cystic fibrosis
- public health
- healthcare
- single cell
- drug induced
- physical activity
- aortic dissection
- cardiovascular events
- genome wide
- electronic health record
- type diabetes
- cardiovascular disease
- coronary artery disease
- metabolic syndrome
- high throughput
- health information
- social media
- dna methylation
- hepatitis b virus
- extracorporeal membrane oxygenation
- skeletal muscle
- adipose tissue
- machine learning
- weight loss
- data analysis
- health promotion
- artificial intelligence