Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.

Ruixue RenYong HeDong DingAoyuan CuiHuarui BaoJing MaXin HouYu LiDechun FengXiaoling LiSuthat LiangpunsakulBin GaoHua Wang

Published in: Hepatology (Baltimore, Md.) (2021)

Aging increases the susceptibility of alcohol-induced liver injury in mice and humans through the down-regulation of the neutrophilic SIRT1-C/EBPα-miR-223 axis, which could be a therapeutic target for the prevention and/or treatment of ALD.

Keyphrases

high fat diet induced
cell proliferation
liver failure
long non coding rna
alcohol consumption
signaling pathway
drug induced
oxidative stress
long noncoding rna
metabolic syndrome
skeletal muscle
aortic dissection
acute respiratory distress syndrome